{"id":52102,"date":"2025-04-25T21:56:14","date_gmt":"2025-04-26T01:56:14","guid":{"rendered":"https:\/\/www.hancockhealth.org\/mayo-health-library\/factor-v-leiden\/"},"modified":"2026-02-04T12:03:24","modified_gmt":"2026-02-04T17:03:24","slug":"factor-v-leiden","status":"publish","type":"mayo","link":"https:\/\/hancockhealth.apgar.digital\/de\/mayo-health-library\/factor-v-leiden\/","title":{"rendered":"Factor V Leiden"},"content":{"rendered":"<div class=\"container mx-auto   wordpress-block wordpress- core-\">\n<p>Factor V Leiden (FAK-tur five LIDE-n) is a mutation of one of the clotting factors in the blood. This mutation can increase your chance of developing abnormal blood clots, most commonly in your legs or lungs.<\/p>\n<p>Most people with factor V Leiden never develop abnormal clots. But in people who do, these abnormal clots can lead to long-term health problems or become life-threatening.<\/p>\n<p>Both men and women can have factor V Leiden. Women who carry the factor V Leiden mutation may have an increased tendency to develop blood clots during pregnancy or when taking the hormone estrogen.<\/p>\n<p>If you have factor V Leiden and have developed blood clots, anticoagulant medications can lessen your risk of developing additional blood clots and help you avoid potentially serious complications.<\/p>\n<p>The factor V Leiden mutation does not itself cause any symptoms. Since factor V Leiden is a risk for developing blood clots in the leg or lungs, the first indication that you have the disorder may be the development of an abnormal blood clot.<\/p>\n<p>Some clots do no damage and disappear on their own. Others can be life-threatening. Symptoms of a blood clot depend on what part of your body is affected.<\/p>\n<h3>A clot in a deep vein<\/h3>\n<p>This is known as deep vein thrombosis (DVT), which most commonly occurs in the legs. A DVT may not cause any symptoms. If signs and symptoms do occur, they can include:<\/p>\n<ul>\n<li>Schmerz<\/li>\n<li>Schwellung<\/li>\n<li>Redness<\/li>\n<li>Warmth<\/li>\n<\/ul>\n<h3>A clot that travels to your lungs<\/h3>\n<p>Known as a pulmonary embolism, this occurs when a portion of a DVT breaks free and travels through the right side of your heart to your lung, where it blocks blood flow. This can be a life-threatening situation. Signs and symptoms may include:<\/p>\n<ul>\n<li>Sudden shortness of breath<\/li>\n<li>Chest pain when breathing in<\/li>\n<li>A cough that produces bloody or blood-streaked sputum<\/li>\n<li>Rapid heartbeat<\/li>\n<\/ul>\n<h3>When to see a doctor<\/h3>\n<p>Seek medical attention immediately if you have signs or symptoms of either a DVT or a pulmonary embolism.<\/p>\n<p>If you have factor V Leiden, you inherited either one copy or, rarely, two copies of the defective gene. Inheriting one copy slightly increases your risk of developing blood clots. Inheriting two copies &mdash; one from each parent &mdash; significantly increases your risk of developing blood clots.<\/p>\n<p>A family history of factor V Leiden increases your risk of inheriting the disorder. The disorder is most common in people who are white and of European descent.<\/p>\n<p>People who have inherited factor V Leiden from only one parent have a 5 percent chance of developing an abnormal blood clot by age 65. Factors that increase this risk include:<\/p>\n<ul>\n<li><strong>Two faulty genes.<\/strong> Inheriting the genetic mutation from both parents instead of just one can significantly increase your risk of abnormal blood clots.<\/li>\n<li><strong>Immobility.<\/strong> Extended periods of immobility, such as sitting during a long airplane flight, can increase the risk of leg clots.<\/li>\n<li><strong>Estrogens.<\/strong> Oral contraceptives, hormone replacement therapy and pregnancy can make you more likely to develop blood clots.<\/li>\n<li><strong>Surgeries or injuries.<\/strong> Surgeries or injuries such as broken bones can increase your risk of abnormal blood clots.<\/li>\n<li><strong>Non-O blood type.<\/strong> Abnormal blood clots are more common in people who have blood types of A, B or AB compared with those with blood type O.<\/li>\n<\/ul>\n<p>Factor V Leiden can cause blood clots in the legs (deep vein thrombosis) and lungs (pulmonary embolism). These blood clots can be life-threatening.<\/p>\n<p>Your doctor may suspect factor V Leiden if you&#8217;ve had one or more episodes of abnormal blood clotting or if you have a strong family history of abnormal blood clots. Your doctor can confirm that you have factor V Leiden with a blood test.<\/p>\n<p>Doctors generally prescribe blood-thinning medications to treat people who develop abnormal blood clots. This type of medicine usually isn&#8217;t needed for people who have the factor V Leiden mutation but who have not experienced abnormal blood clots.<\/p>\n<p>However, your doctor might suggest that you take extra precautions to prevent blood clots if you have the factor V Leiden mutation and are going to have surgery. These precautions might include:<\/p>\n<ul>\n<li>A short course of blood thinners<\/li>\n<li>Leg wraps that inflate and deflate to keep blood moving in your legs<\/li>\n<li>Compression stockings<\/li>\n<li>Going for walks soon after surgery<\/li>\n<\/ul>\n<p>Some precautions to help reduce your risk of blood clots include:<\/p>\n<ul>\n<li><strong>Keep your legs moving.<\/strong> When your legs remain still for hours, your calf muscles don&#8217;t contract, which normally helps blood circulate. If you&#8217;re on a long plane trip, raise your toes up and down and rotate your ankles every hour or so. Drink extra water to prevent dehydration, and avoid alcohol. On a car trip, take periodic breaks and walk around.<\/li>\n<li><strong>Consider compression stockings.<\/strong> These types of socks, which usually come up to the knees, help improve blood circulation in your legs. Ask your doctor if they might be a good option for your situation.<\/li>\n<li><strong>Be cautious with estrogen.<\/strong> Oral contraceptives or estrogen replacement therapy can increase the risk of blood clots on their own, so be sure to discuss the risks and the benefits of estrogen-containing medications with your doctor if you have factor V Leiden.<\/li>\n<\/ul>\n<h3>Prevent excessive bleeding<\/h3>\n<p>If your factor V Leiden requires you to take anticoagulant medication, here are some steps that might help you prevent injury and avoid excessive bleeding:<\/p>\n<ul>\n<li><strong>Avoid playing contact sports<\/strong> or engaging in other activities that could result in physical injury. Regular noncontact exercise, such as walking or swimming, is still recommended for good health.<\/li>\n<li><strong>Use a soft toothbrush<\/strong> and waxed floss.<\/li>\n<li><strong>Avoid shaving cuts<\/strong> by using an electric razor.<\/li>\n<li><strong>Be cautious with household tasks<\/strong> involving knives, scissors and other sharp tools.<\/li>\n<\/ul>\n<p>Your doctor may refer you to a specialist in genetic disorders (geneticist) or a specialist in blood disorders (hematologist) for testing to determine whether the cause of your blood clots is genetic and, specifically, whether you have factor V Leiden.<\/p>\n<p>Here&#8217;s some information to help you prepare for your appointment.<\/p>\n<ul>\n<li><strong>List any symptoms you&#8217;re experiencing,<\/strong> including any that may seem unrelated to the reason for which you scheduled the appointment.<\/li>\n<li><strong>List your health history,<\/strong> including your history of blood clots. Include any family history of blood clots or known family members with factor V Leiden.<\/li>\n<li><strong>Make a list of all medications,<\/strong> vitamins or supplements you&#8217;re taking, along with the dose for each.<\/li>\n<li><strong>List questions to ask<\/strong> dein Arzt.<\/li>\n<\/ul>\n<p>For factor V Leiden, some basic questions to ask your doctor include:<\/p>\n<ul>\n<li>What kinds of tests do I need?<\/li>\n<li>Do I need to see a specialist?<\/li>\n<li>Does my factor V Leiden need to be treated?<\/li>\n<li>Do I need to take medication to prevent additional blood clots?<\/li>\n<li>What types of side effects can I expect from the medication?<\/li>\n<li>Do I need to limit my activity in any way?<\/li>\n<li>If I have children, do they need to be tested?<\/li>\n<li>Do you have any brochures or other printed material that I can take with me? What websites do you recommend?<\/li>\n<\/ul>\n<p>If your doctor recommends genetic testing, some questions you might want to ask the genetic specialist include:<\/p>\n<ul>\n<li>How accurate is this test?<\/li>\n<li>What are the risks of the test?<\/li>\n<li>What information will come out of the test?<\/li>\n<li>What will a positive or negative result tell me?<\/li>\n<li>Can the results of the test affect my ability to obtain health insurance?<\/li>\n<li>Is an uncertain result possible, and what would that mean?<\/li>\n<li>What are my treatment options if a mutation is found?<\/li>\n<li>Could other family members be affected?<\/li>\n<li>Should my children be tested?<\/li>\n<li>What measures are in place to protect my privacy?<\/li>\n<li>How experienced is the lab at performing this test?<\/li>\n<li>How long will it take to get results back?<\/li>\n<\/ul>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>This inherited clotting disorder can increase your chance of developing abnormal blood clots, most commonly in your legs or lungs.<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","template":"","tags":[1686,1685,1682],"class_list":["post-52102","mayo","type-mayo","status-publish","hentry","tag-anatomical-structure","tag-condition","tag-person-group-concept","content_type-diseases-conditions"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.6 - 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