{"id":52478,"date":"2025-04-25T22:02:25","date_gmt":"2025-04-26T02:02:25","guid":{"rendered":"https:\/\/www.hancockhealth.org\/mayo-health-library\/what-is-aspirin-exacerbated-respiratory-disease-aerd\/"},"modified":"2026-02-04T12:05:47","modified_gmt":"2026-02-04T17:05:47","slug":"what-is-aspirin-exacerbated-respiratory-disease-aerd","status":"publish","type":"mayo","link":"https:\/\/hancockhealth.apgar.digital\/es\/mayo-health-library\/what-is-aspirin-exacerbated-respiratory-disease-aerd\/","title":{"rendered":"What is aspirin-exacerbated respiratory disease (AERD)?"},"content":{"rendered":"<div class=\"container mx-auto   wordpress-block wordpress- core-\">\n<p>Aspirin-exacerbated respiratory disease (AERD), also called Samter&#8217;s triad, has three features:<\/p>\n<ul>\n<li><strong>Asthma,<\/strong> although only a small number of people with asthma will develop <abbr title=\"aspirin-exacerbated respiratory disease\">AERD<\/abbr>.<\/li>\n<li><strong>Nasal polyps that often come back,<\/strong> even after taken out by surgery.<\/li>\n<li><strong>Problems with taking aspirin and nonsteroidal anti-inflammatory drugs (NSAIDs),<\/strong> such as ibuprofen (Advil, Motrin IB, others) and naproxen. Keep in mind that aspirin or <abbr title=\"nonsteroidal anti-inflammatory drugs\">NSAIDs<\/abbr> may be in cold medicines and other medicines.<\/li>\n<\/ul>\n<p>Usually, warning signs of <abbr title=\"aspirin-exacerbated respiratory disease\">AERD<\/abbr> don&#8217;t show up until people have reached their 30s or 40s, but <abbr title=\"aspirin-exacerbated respiratory disease\">AERD<\/abbr> can sometimes happen in children.<\/p>\n<p>Problems usually start suddenly and can be serious. Symptoms may include trouble breathing, which could be an asthma flare-up, wheezing, coughing, sneezing, and a stuffy or runny nose. Some people with <abbr title=\"aspirin-exacerbated respiratory disease\">AERD<\/abbr> also have these types of problems if they drink alcohol, such as beer or wine.<\/p>\n<p>The exact cause of <abbr title=\"aspirin-exacerbated respiratory disease\">AERD<\/abbr> is not known but it is not an allergic response. There is no proof to show that it&#8217;s genetic or inherited. The disease is not caused by taking aspirin or <abbr title=\"nonsteroidal anti-inflammatory drugs\">NSAIDs<\/abbr>, but <abbr title=\"aspirin-exacerbated respiratory disease\">AERD<\/abbr> sinus or asthma symptoms get worse when taking these medicines.<\/p>\n<p>There is no special test to find <abbr title=\"aspirin-exacerbated respiratory disease\">AERD<\/abbr>. There are lab tests that can help in finding the cause of your illness. There is a blood test to look for higher than usual levels of white blood cells called eosinophils. And there is a urine test to look for raised leukotrienes, which are chemicals that can cause tightening of the airways. <abbr title=\"Aspirin-exacerbated respiratory disease\">AERD<\/abbr> also may affect your sense of smell. Finding <abbr title=\"aspirin-exacerbated respiratory disease\">AERD<\/abbr> is possible if you have all three of these things: asthma, nasal polyps, and respiratory problems when taking aspirin or <abbr title=\"nonsteroidal anti-inflammatory drugs\">NSAIDs<\/abbr>.<\/p>\n<p>When it&#8217;s not clear whether you have a problem taking aspirin or <abbr title=\"nonsteroidal anti-inflammatory drugs\">NSAIDs<\/abbr>, your health care provider may do an aspirin challenge called desensitization. This is done to check if you have <abbr title=\"aspirin-exacerbated respiratory disease\">AERD<\/abbr>. Your provider and medical team give you aspirin in a safe medical surrounding and follow special safety rules.<\/p>\n<p>There is no cure for <abbr title=\"aspirin-exacerbated respiratory disease\">AERD<\/abbr>, but several treatments can be given, depending on your illness. A blend of treatments often work best. Choices are:<\/p>\n<ul>\n<li>Stay away from aspirin and <abbr title=\"nonsteroidal anti-inflammatory drugs\">NSAIDs<\/abbr>, unless your health care provider prescribes desensitization to aspirin.<\/li>\n<li>Taking medicines to treat asthma, such as corticosteroids that you breathe in.<\/li>\n<li>Surgery to remove nasal polyps, although they can come back.<\/li>\n<li>Taking medicines such as montelukast (Singulair, zafirlukast (Accolate) or zileuton (Zyflo) to block leukotrienes.<\/li>\n<li>Injecting man-made proteins into your body that connect to certain targets. These proteins, called monoclonal antibodies, try to affect cells that are causing your problem.<\/li>\n<li>Having desensitization to aspirin. Aspirin is given in the health care provider&#8217;s office in slowly increasing doses over two days. After that, it is taken daily at high doses, which may help lessen the need for oral steroids. It also may stop nasal polyps from coming back.<\/li>\n<\/ul>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>AERD, also called Samter&#8217;s triad, has three features: asthma, recurring nasal polyps, and sensitivity to aspirin and drugs such as ibuprofen and naproxen.<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","template":"","tags":[1686,1685,1682,1684],"class_list":["post-52478","mayo","type-mayo","status-publish","hentry","tag-anatomical-structure","tag-condition","tag-person-group-concept","tag-theme-of-focus","content_type-articles"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.6 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>What is aspirin-exacerbated respiratory disease (AERD)? - Hancock Health<\/title>\n<meta name=\"robots\" content=\"noindex, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<meta property=\"og:locale\" content=\"es_MX\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"What is aspirin-exacerbated respiratory disease (AERD)? 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